Host: Rabbit
Target Protein: Phospho-FAK (Tyr925)
IR: Immunogen Range:V(p-Y)EN
Clonality: Polyclonal
Isotype: IgG
Entrez Gene: 5747
Swiss Prot: Q05397
Source: KLH conjugated synthesised phosphopeptide derived from human FAK around the phosphorylation site of Tyr925:V(p-Y)EN
Purification: affinity purified by Protein A
Storage: 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Background: Non-receptor protein-tyrosine kinase implicated in signaling pathways involved in cell motility, proliferation and apoptosis. Activated by tyrosine-phosphorylation in response to either integrin clustering induced by cell adhesion or antibody cross-linking, or via G-protein coupled receptor (GPCR) occupancy by ligands such as bombesin or lysophosphatidic acid, or via LDL receptor occupancy. Plays a potential role in oncogenic transformations resulting in increased kinase activity. [SUBCELLULAR LOCATION] Cell junction, focal adhesion. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Note=Constituent of focal adhesions.
Size: 200ul
Concentration: 1mg/ml
Applications: WB=1:500-2000, IHC-P=1:100-500, IHC-F=1:100-500, IF=1:100-500
Cross Reactive Species: Human,Mouse (predicted: Rat,Chicken,Dog,Cow,Horse,Rabbit)
For research use only. Not intended for diagnostic or therapeutic use.