Host: Rabbit
Target Protein: VP16 tag
IR: Immunogen Range:391-490/490aa
Clonality: Polyclonal
Isotype: IgG
Entrez Gene: VP16 tag
Swiss Prot: P04486
Source: KLH conjugated synthetic peptide derived from HSV-1 VP16:391-490/490aa
Purification: affinity purified by Protein A
Storage: 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Background: HSV evades the immune system through interference with MHC class I antigen presentation on the cell surface, by blocking TAP or the transporter associated with antigen processing induced by the secretion of ICP-47 by HSV. In the host cell, TAP transports digested viral antigen epitope peptides from the cytosol to the endoplasmic reticulum, allowing these epitopes to be combined with MHC class I molecules and presented on the surface of the cell. Viral epitope presentation with MHC class I is a requirement for activation of cytotoxic T-lymphocytes (CTLs), the major effectors of the cell-mediated immune response against virally-infected cells. ICP-47 prevents initiation of a CTL-response against HSV, allowing the virus to survive for a protracted period in the host.
Size: 200ul
Concentration: 1mg/ml
Applications: WB=1:1000-5000, ELISA=1:5000-10000
Cross Reactive Species: Species independent
For research use only. Not intended for diagnostic or therapeutic use.