Host: Mouse
Target Protein: Alpha-actinin-1
IR: Immunogen Range:
Clonality: Monoclonal
Isotype: IgG
Entrez Gene: 87
Swiss Prot: P12814
Source: Recombinant human Alpha-actinin-1 protein 1-205/894 (C-6x His-Tag):
Purification: affinity purified by Protein G
Storage: 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
Background: Alpha actinins belong to the spectrin gene superfamily which represents a diverse group of cytoskeletal proteins, including the alpha and beta spectrins and dystrophins. Alpha actinin is an actin-binding protein with multiple roles in different cell types. In nonmuscle cells, the cytoskeletal isoform is found along microfilament bundles and adherens-type junctions, where it is involved in binding actin to the membrane. In contrast, skeletal, cardiac, and smooth muscle isoforms are localized to the Z-disc and analogous dense bodies, where they help anchor the myofibrillar actin filaments. This gene encodes a nonmuscle, cytoskeletal, alpha actinin isoform and maps to the same site as the structurally similar erythroid beta spectrin gene. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Size: 200ul
Concentration: 1mg/ml
Applications: IHC-P=1:100-500, IHC-F=1:500-1000, ICC=1:100-500, IF=1:500-1000, ELISA=1:5000-10000
Cross Reactive Species: (predicted: Human,Mouse,Rat)
For research use only. Not intended for diagnostic or therapeutic use.