Host: Mouse
Target Protein: Caspase 8
IR: Immunogen Range:
Clonality: Monoclonal
Isotype: IgG
Entrez Gene: 841
Swiss Prot: Q14790
Source: Recombinant human Caspase 8 Protein :
Purification: affinity purified by Protein G
Storage: 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Background: Caspases are cysteine proteases, expressed as inactive precursors, that mediate apoptosis by proteolysis of specific substrates. Caspases have the ability to cleave after aspartic acid residues. There are two classes of caspases involved in apoptosis; initiators (activation by receptor cluster) and effectors (activation by mitochondrial permeability transition). Proapoptotic signals autocatalytically activate initiator caspases, such as Caspase 8 and Caspase 9. Activated initiator caspases then process effector caspases, such as Caspase 3 and Caspase 7, which in turn cause cell collapse.
Size: 50ul
Concentration: 1mg/ml
Applications: WB=1:2000-5000, IHC-P=1:400-1000, IHC-F=1:500-1000, IF=1:500-1000, ELISA=1:5000-10000
Cross Reactive Species: Human,Mouse (predicted: Rat)
For research use only. Not intended for diagnostic or therapeutic use.