Host: Mouse

Target Protein: phospho-MLKL (Ser358)

IR: Immunogen Range:QT(p-S)MS

Clonality: Monoclonal

Isotype: IgG

Entrez Gene: 197259

Swiss Prot: Q8NB16

Source: KLH conjugated Synthesised monomethylpeptide derived from human MLKL around the phosphorylation site of Ser358:QT(p-S)MS 

Purification: affinity purified by Protein G

Storage: 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.

Background: This gene belongs to the protein kinase superfamily. The encoded protein contains a protein kinase-like domain; however, is thought to be inactive because it lacks several residues required for activity. This protein plays a critical role in tumor necrosis factor (TNF)-induced necroptosis, a programmed cell death process, via interaction with receptor-interacting protein 3 (RIP3), which is a key signaling molecule in necroptosis pathway. Inhibitor studies and knockdown of this gene inhibited TNF-induced necrosis. High levels of this protein and RIP3 are associated with inflammatory bowel disease in children. Alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Sep 2015].