Host: Rabbit
Target Protein: PAK6
IR: Immunogen Range:
Clonality: Polyclonal
Isotype: IgG
Entrez Gene: 56924
Swiss Prot: Q9NQU5
Source: KLH conjugated synthetic peptide derived from human PAK6:
Purification: affinity purified by Protein A
Storage: 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Background: This gene encodes a protein that shares a high degree of sequence similarity with p21-activated kinase (PAK) family members. The proteins of this family are Rac/Cdc42-associated Ste20-like Ser/Thr protein kinases, characterized by a highly conserved amino-terminal Cdc42/Rac interactive binding (CRIB) domain and a carboxyl-terminal kinase domain. PAK kinases are implicated in the regulation of a number of cellular processes, including cytoskeleton rearrangement, apoptosis and the MAP kinase signaling pathway. The protein encoded by this gene was found to interact with androgen receptor (AR), which is a steroid hormone-dependent transcription factor that is important for male sexual differentiation and development. The p21-activated protein kinase 6 gene was found to be highly expressed in testis and prostate tissues and the encoded protein was shown to cotranslocate into the nucleus with AR in response to androgen.
Size: 50ul
Concentration: 1mg/ml
Applications: WB=1:300-1000, IHC-P=1:100-500, ELISA=1:5000-10000
Cross Reactive Species: Mouse (predicted: Human)
For research use only. Not intended for diagnostic or therapeutic use.