Host: Rabbit
Target Protein: FBH1
IR: Immunogen Range:1-100/1043
Clonality: Polyclonal
Isotype: IgG
Entrez Gene: 84893
Swiss Prot: Q8NFZ0
Source: KLH conjugated synthetic peptide derived from human FBXO18 :1-100/1043
Purification: affinity purified by Protein A
Storage: 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Background:
FBXO18 belongs to the F-box protein family, whose members share the F-box, an approximately 40 amino acid motif. It has both DNA-dependent ATPase and DNA unwinding activities.
FBXO18 is a 1,043 amino acid protein encoded by the human gene FBXO18. FBXO18 belongs to the helicase family (UvrD subfamily) and contains one F-box domain. This nuclear protein is a DNA-dependent ATPase that unwinds double-stranded DNA in a 3' to 5' direction. FBXO18 also recognizes and binds to a variety of phosphorylated proteins and promotes their ubiquitination and degradation. It also interacts with Skp1 in the SCF E3 ubiquitin ligase complex consisting of Skp1, CUL-1, Rbx1 and FBXO18.
Size: 100ul
Concentration: 1mg/1ml
Applications: WB=1:500-2000, ELISA=1:5000-10000
Cross Reactive Species: (predicted: Human,Mouse,Rat,Horse,Rabbit)
For research use only. Not intended for diagnostic or therapeutic use.