Host: Rabbit

Target Protein: BMPR2

IR: Immunogen Range:621-720/1038

Clonality: Polyclonal

Isotype: IgG

Entrez Gene: 659

Swiss Prot: Q13873

Source: KLH conjugated synthetic peptide derived from human BMPR2:621-720/1038 

Purification: affinity purified by Protein A

Storage: 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.

Background: On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Binds to BMP-7, BMP-2 and, less efficiently, BMP-4. Binding is weak but enhanced by the presence of type I receptors for BMPs.