Host: Rabbit
Target Protein: ErbB 4
IR: Immunogen Range:21-120/1308
Clonality: Polyclonal
Isotype: IgG
Entrez Gene: 2066
Swiss Prot: Q15303
Source:
KLH conjugated synthetic peptide derived from human ErbB 4 :21-120/1308
Purification: affinity purified by Protein A
Storage: 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Background: This gene is a member of the Tyr protein kinase family and the epidermal growth factor receptor subfamily. It encodes a single-pass type I membrane protein with multiple cysteine rich domains, a transmembrane domain, a tyrosine kinase domain, a phosphotidylinositol-3 kinase binding site and a PDZ domain binding motif. The protein binds to and is activated by neuregulins and other factors and induces a variety of cellular responses including mitogenesis and differentiation. Multiple proteolytic events allow for the release of a cytoplasmic fragment and an extracellular fragment. Mutations in this gene have been associated with cancer. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized. [provided by RefSeq, Jul 2008].
Size: 200ul
Concentration: 1mg/ml
Applications: IHC-P=1:100-500
Cross Reactive Species: Human,Mouse (predicted: Rat,Chicken,Dog,Horse,Rabbit)
For research use only. Not intended for diagnostic or therapeutic use.