Host: Mouse

Target Protein: Estrogen Receptor α(ready to use)

IR: Immunogen Range:

Clonality: Monoclonal

Isotype: IgG2b

Entrez Gene: 2099

Swiss Prot: P03372

Source: human Estrogen Receptor α: 

Purification: affinity purified by Protein G

Storage: 0.01M PBS(pH7.4) with 1% BSA and 0.1% Proclin300 Store at 2-8 °C for one year. Avoid repeated freeze/thaw cycles.

Background: Estrogen and progesterone receptor are members of a family of transcription factors that are regulated by the binding of their cognate ligands. The interaction of hormone-bound estrogen receptors with estrogen responsive elements(EREs) alters transcription of ERE-containing genes. The carboxy terminal region of the estrgen receptor contains the ligand binding domain, the amino terminus serves as the transactivation domain, and the DNA binding domain is centrally located. Two forms of estrogen receptor have been identified, ER Alpha and ER Beta. ER Alpha and ER Beta have been shown to be differentially activated by various ligands. The biological response to progesterone is mediated by two distinct forms of the human progesterone receptor (hPR-A and hPR-B), which arise from alternative splicing. In most cells, hPR-B functions as a transcriptional activator of progesterone-responsive gene, whereas hPR-A function as a transcriptional inhibitor of all steroid hormone receptors.