Host: Rabbit
Target Protein: GIPC1
IR: Immunogen Range:171-270/333
Clonality: Polyclonal
Isotype: IgG
Entrez Gene: 10755
Swiss Prot: O14908
Source: KLH conjugated synthetic peptide derived from human GIPC1:171-270/333
Purification: affinity purified by Protein A
Storage: 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Background: GIPC, for GAIP interacting protein at the C terminus (also designated SEMCAP-1 or synectin), is a PDZ domain containing protein that interacts with RGS-GAIP, a GTPase-activating protein (GAP) for G(a i) subunits. GIPC was also identified as TIP-2, a protein that interacts with the viral oncoprotein TAX, which transactivates viral and cellular promoters through interactions with various transcription factors. PDZ domain-containing proteins are primarily localized to cell-cell junctions in epithelial cells and neurons where they coordinate the assembly of multiprotein complexes. GIPC specifically localizes to clusters of vesicles near the plasma membrane and participates in G protein-coupled signaling pathway involved in regulating clathrin-coated vesicular trafficking. GIPC also associates with membrane bound semaphorin F (M-SemF), which is involved in neuronal axon growth, and it appears to regulate the subcellular distribution of M-SemF in the brain.
Size: 200ul
Concentration: 1mg/ml
Applications: WB=1:500-2000
Cross Reactive Species: Mouse,Rat (predicted: Human,Cow,Sheep)
For research use only. Not intended for diagnostic or therapeutic use.