Host: Rabbit
Target Protein: phospho-BRAF (Thr401)
IR: Immunogen Range:SA(p-T)PP
Clonality:
Isotype: IgG
Entrez Gene: 673
Swiss Prot: P15056
Source: KLH conjugated Synthesised phosphopeptide derived from human BRAF around the phosphorylation site of Thr401:SA(p-T)PP
Purification: affinity purified by Protein A
Storage: 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Background: This gene encodes a protein belonging to the RAF family of serine/threonine protein kinases. This protein plays a role in regulating the MAP kinase/ERK signaling pathway, which affects cell division, differentiation, and secretion. Mutations in this gene, most commonly the V600E mutation, are the most frequently identified cancer-causing mutations in melanoma, and have been identified in various other cancers as well, including non-Hodgkin lymphoma, colorectal cancer, thyroid carcinoma, non-small cell lung carcinoma, hairy cell leukemia and adenocarcinoma of lung. Mutations in this gene are also associated with cardiofaciocutaneous, Noonan, and Costello syndromes, which exhibit overlapping phenotypes. A pseudogene of this gene has been identified on the X chromosome. [provided by RefSeq, Aug 2017]
Size: 50ul
Concentration: 1mg/ml
Applications: WB=1:1000-2000, ICC=1:100-500, IF=1:100-500
Cross Reactive Species: Human,Mouse,Rat
For research use only. Not intended for diagnostic or therapeutic use.