Host: Rabbit

Target Protein: Phospho-RPS6KA1 (Ser380)

IR: Immunogen Range:GF(p-S)FV

Clonality:

Isotype: IgG

Entrez Gene: 6195

Swiss Prot: Q15418

Source: KLH conjugated Synthesised phosphopeptide derived from human RPS6KA1 around the phosphorylation site of Ser380:GF(p-S)FV 

Purification: affinity purified by Protein A

Storage: 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.

Background: Rsk1 is a member of a family of 90kDa ribosomal protein S6 kinases, which includes Rsk1, Rsk2 and Rsk3. These are broadly expressed serine/threonine protein kinases activated in response to mitogenic stimuli, including extracellular signal regulated protein kinases Erk1 and Erk2. Rsk1 is activated by MAPK in vitro and in vivo via phosphorylation. Active Rsks appear to play a major role in transcriptional regulation by translocating to the nucleus and phosphorylating c Fos and CREB.