Host: Mouse
Target Protein: ZAP70
IR: Immunogen Range:
Clonality: Monoclonal
Isotype: IgG1,k
Entrez Gene: 7535
Swiss Prot: P43403
Source: Recombinant human ZAP70.:
Purification: affinity purified by Protein G
Storage: 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Background: This gene encodes an enzyme belonging to the protein tyrosine kinase family, and it plays a role in T-cell development and lymphocyte activation. This enzyme, which is phosphorylated on tyrosine residues upon T-cell antigen receptor (TCR) stimulation, functions in the initial step of TCR-mediated signal transduction in combination with the Src family kinases, Lck and Fyn. This enzyme is also essential for thymocyte development. Mutations in this gene cause selective T-cell defect, a severe combined immunodeficiency disease characterized by a selective absence of CD8-positive T-cells. Two transcript variants that encode different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Size: 50ul
Concentration: 1mg/ml
Applications: WB=1:500-2000, ICC=1:25, IF=1:25, Flow-Cyt=1:25
Cross Reactive Species: Human
For research use only. Not intended for diagnostic or therapeutic use.