Host: Rabbit

Target Protein: phospho-Bim (Ser87)

IR: Immunogen Range:RS(p-S)LL

Clonality: Polyclonal

Isotype: IgG

Entrez Gene: 10018

Swiss Prot: O43521

Source: KLH conjugated Synthesised phosphopeptide derived from human Bim around the phosphorylation site of Ser87:RS(p-S)LL 

Purification: affinity purified by Protein A

Storage: 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.

Background: Bim, Bcl-2 interacting mediator of cell death, is a pro-apoptotic protein belonging to the Bcl2 family of proteins containing a Bcl2 homology domain 3 (BH3). It is proapoptotic and exerts its effects by interacting with prosurvival members of the Bcl2 family like Bcl2, BclxL and Bclw. Bim is sequestered in an inactive conformation through binding to the microtubule-associated dynein motor complex. Certain apoptotic stimuli release Bim from microtubules, allowing inhibitory binding to anti-apoptotic Bcl-2 family members and subsequent iniation of apoptosis.