Host: Rabbit
Target Protein: SUN2
IR: Immunogen Range:
Clonality:
Isotype: IgG
Entrez Gene: 25777
Swiss Prot: Q9UH99
Source: Recombinant protein within human SUN2 aa 500-700.:
Purification: affinity purified by Protein A
Storage: 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Background: SUN1 (MIM 607723) and SUN2 are inner nuclear membrane (INM) proteins that play a major role in nuclear-cytoplasmic connection by formation of a 'bridge' across the nuclear envelope, known as the LINC complex, via interaction with the conserved luminal KASH domain of nesprins (e.g., SYNE1; MIM 608441) located in the outer nuclear membrane (ONM). The LINC complex provides a direct connection between the nuclear lamina and the cytoskeleton, which contributes to nuclear positioning and cellular rigidity (summary by Haque et al., 2010 [PubMed 19933576]).[supplied by OMIM, Nov 2010]
Size: 100ul
Concentration: 1mg/ml
Applications: WB=1:500-2000, IHC-P=1:100-500, ICC=1:50-100
Cross Reactive Species:
For research use only. Not intended for diagnostic or therapeutic use.