Host: Rabbit

Target Protein: KSR1

IR: Immunogen Range:601-750/921

Clonality: Polyclonal

Isotype: IgG

Entrez Gene: 8844

Swiss Prot: Q8IVT5

Source: KLH conjugated synthetic peptide derived from human KSR1:601-750/921 

Purification: affinity purified by Protein A

Storage: 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.

Background: KSR1 is a molecular scaffold and positive regulator of the Raf/MEK/ERK phosphorylation cascade. It was initially considered to be a protein kinase acting in the Ras pathway. KSR1 is required for maximal ERK activation induced by growth factors and by some cytotoxic agents. In resting cells, phosphorylated KSR1 is cytoplasmic and in stimulated cells, dephosphorylated KSR1 is membrane associated.