Host: Rabbit
Target Protein: LATS1
IR: Immunogen Range:821-950/1130
Clonality: Polyclonal
Isotype: IgG
Entrez Gene: 9113
Swiss Prot: O95835
Source: KLH conjugated synthetic peptide derived from human LATS1:821-950/1130
Purification: affinity purified by Protein A
Storage: 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Background: The protein encoded by this gene is a putative serine/threonine kinase that localizes to the mitotic apparatus and complexes with cell cycle controller CDC2 kinase in early mitosis. The protein is phosphorylated in a cell-cycle dependent manner, with late prophase phosphorylation remaining through metaphase. The N-terminal region of the protein binds CDC2 to form a complex showing reduced H1 histone kinase activity, indicating a role as a negative regulator of CDC2/cyclin A. In addition, the C-terminal kinase domain binds to its own N-terminal region, suggesting potential negative regulation through interference with complex formation via intramolecular binding. Biochemical and genetic data suggest a role as a tumor suppressor. This is supported by studies in knockout mice showing development of soft-tissue sarcomas, ovarian stromal cell tumors and a high sensitivity to carcinogenic treatments. [provided by RefSeq].
Size: 50ul
Concentration: 1mg/ml
Applications: WB=1:500-2000, IHC-P=1:100-500, ICC=1:25, ELISA=1:5000-10000
Cross Reactive Species: Human (predicted: Rabbit,Horse,Cow,Pig,Chicken,Rat,Mouse)
For research use only. Not intended for diagnostic or therapeutic use.