Host: Rabbit
Target Protein: Phospho-Mcl1 (Ser159 + Thr163)
IR: Immunogen Range:DG(p-S)LPS(p-T)PP
Clonality: Polyclonal
Isotype: IgG
Entrez Gene: 4170
Swiss Prot: Q07820
Source: KLH conjugated synthesised phosphopeptide derived from human Mcl 1 around the phosphorylation site of Ser159/Thr163:DG(p-S)LPS(p-T)PP
Purification: affinity purified by Protein A
Storage: 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Background: Mcl1 is an anti-apoptotic member of Bcl2 family originally isolated from the ML1 human myeloid leukemia cell line during phorbol ester-induced differentiation along the monocyte/macrophage pathway. Mcl1 localizes to the mitochondria, interacts with and antagonizes pro-apoptotic Bcl2 family members, and inhibits apoptosis by a number of cytotoxic stimuli. It is involved in programing of differentiation and concomitant maintenance of viability but not of proliferation. Isoform 1 inhibits apoptosis while isoform 2 promotes it. Expression increases early during phorbol-ester induced differentiation along the monocyte/macrophage pathway in myeloid leukemia cell lines ML1.
Size: 100ul
Concentration: 1mg/ml
Applications: IHC-P=1:100-500, IHC-F=1:100-500, ICC=1:100, IF=1:100-500, Flow-Cyt=1ug/Test, ELISA=1:5000-10000
Cross Reactive Species: Human,Rat (predicted: Mouse,Dog,Cow,Horse)
For research use only. Not intended for diagnostic or therapeutic use.