Host: Rabbit

Target Protein: Phospho-Mcl1 (Ser159 + Thr163)

IR: Immunogen Range:DG(p-S)LPS(p-T)PP

Clonality: Polyclonal

Isotype: IgG

Entrez Gene: 4170

Swiss Prot: Q07820

Source: KLH conjugated synthesised phosphopeptide derived from human Mcl 1 around the phosphorylation site of Ser159/Thr163:DG(p-S)LPS(p-T)PP 

Purification: affinity purified by Protein A

Storage: 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.

Background: Mcl1 is an anti-apoptotic member of Bcl2 family originally isolated from the ML1 human myeloid leukemia cell line during phorbol ester-induced differentiation along the monocyte/macrophage pathway. Mcl1 localizes to the mitochondria, interacts with and antagonizes pro-apoptotic Bcl2 family members, and inhibits apoptosis by a number of cytotoxic stimuli. It is involved in programing of differentiation and concomitant maintenance of viability but not of proliferation. Isoform 1 inhibits apoptosis while isoform 2 promotes it. Expression increases early during phorbol-ester induced differentiation along the monocyte/macrophage pathway in myeloid leukemia cell lines ML1.