Host: Rabbit

Target Protein: Phospho-Tie2 (Tyr992)

IR: Immunogen Range:EV(p-Y)VK

Clonality: Polyclonal

Isotype: IgG

Entrez Gene: 7010

Swiss Prot: Q02763

Source: KLH conjugated Synthesised phosphopeptide derived from human Tie2 around the phosphorylation site of Tyr992:EV(p-Y)VK 

Purification: affinity purified by Protein A

Storage: 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.

Background: The TEK receptor tyrosine kinase is expressed almost exclusively in endothelial cells in mice, rats, and humans. This receptor possesses a unique extracellular domain containing 2 immunoglobulin-like loops separated by 3 epidermal growth factor-like repeats that are connected to 3 fibronectin type III-like repeats. The ligand for the receptor is angiopoietin-1. Defects in TEK are associated with inherited venous malformations; the TEK signaling pathway appears to be critical for endothelial cell-smooth muscle cell communication in venous morphogenesis.TEK is closely related to the TIE receptor tyrosine kinase.