Host: Rabbit

Target Protein: Phospho-ATG1 (Ser556)

IR: Immunogen Range:LH(p-S)AP

Clonality: Polyclonal

Isotype: IgG

Entrez Gene: 8408

Swiss Prot: O75385

Source: KLH conjugated Synthesised phosphopeptide derived from human ATG1/ULK1 around the phosphorylation site of Ser556:LH(p-S)AP 

Purification: affinity purified by Protein A

Storage: 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.

Background: ULK1 belongs to the serine/threonine protein kinase family. It is involved in axon growth and plays an essential role in neurite branching during sensory axon outgrowth. Knockdown of ULK1 results in impaired endocytosis of nerve growth factor (NGF), excessive axon arborization, and severely stunted axon elongation indicating that ULK1 mediates a non clathrin coated endocytosis in sensory growth cones. Knockdown of ULK1 also inhibits the autophagic response. It appears to act as a convergence point for multiple signals that regulate autophagy, and in turn interacts with a large number of autophagy related (Atg) proteins.