Host: Rabbit
Target Protein: Phospho-ZAP70 (Tyr493)
IR: Immunogen Range:SY(p-Y)TA
Clonality: Polyclonal
Isotype: IgG
Entrez Gene: 7535
Swiss Prot: P43403
Source: KLH conjugated Synthesised phosphopeptide derived from human Zap-70 around the phosphorylation site of Tyr493:SY(p-Y)TA
Purification: affinity purified by Protein A
Storage: 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Background: This gene encodes an enzyme belonging to the protein tyrosine kinase family, and it plays a role in T-cell development and lymphocyte activation. This enzyme, which is phosphorylated on tyrosine residues upon T-cell antigen receptor (TCR) stimulation, functions in the initial step of TCR-mediated signal transduction in combination with the Src family kinases, Lck and Fyn. This enzyme is also essential for thymocyte development. Mutations in this gene cause selective T-cell defect, a severe combined immunodeficiency disease characterized by a selective absence of CD8-positive T-cells. Two transcript variants that encode different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].
Size: 100ul
Concentration: 1mg/ml
Applications: WB=1:500-2000, IHC-F=1:100-500, ICC=1:100-500, IF=1:100-500, ELISA=1:5000-10000
Cross Reactive Species: Human (predicted: Mouse,Rat,Pig,Cow,Horse,Rabbit)
For research use only. Not intended for diagnostic or therapeutic use.