Host: Rabbit
Target Protein: OGG1
IR: Immunogen Range:151-250/424
Clonality: Polyclonal
Isotype: IgG
Entrez Gene: 4968
Swiss Prot: O15527
Source: KLH conjugated synthetic peptide derived from human OGG1/8 hydroxyguanine DNA glycosylase:151-250/424
Purification: affinity purified by Protein A
Storage: 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Background: This gene encodes the enzyme responsible for the excision of 8-oxoguanine, a mutagenic base byproduct which occurs as a result of exposure to reactive oxygen. The action of this enzyme includes lyase activity for chain cleavage. Alternative splicing of the C-terminal region of this gene classifies splice variants into two major groups, type 1 and type 2, depending on the last exon of the sequence. Type 1 alternative splice variants end with exon 7 and type 2 end with exon 8. All variants share the N-terminal region in common, which contains a mitochondrial targeting signal that is essential for mitochondrial localization. Many alternative splice variants for this gene have been described, but the full-length nature for every variant has not been determined. [provided by RefSeq, Aug 2008].
Size: 100ul
Concentration: 1mg/ml
Applications: WB=1:500-2000, IHC-P=1:100-500, IHC-F=1:100-500, ELISA=1:5000-10000
Cross Reactive Species: Rat,Mouse,Human (predicted: Cow,Pig,Dog)
For research use only. Not intended for diagnostic or therapeutic use.