Host: Rabbit

Target Protein: PITX3

IR: Immunogen Range:231-302/302

Clonality: Polyclonal

Isotype: IgG

Entrez Gene: 5309

Swiss Prot: O75364

Source: KLH conjugated synthetic peptide derived from human PITX3:231-302/302 

Purification: affinity purified by Protein A

Storage: 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.

Background: The transcription factor PITX3 is expressed selectively in the midbrain and regulates the differentiation and survival of dopaminergic neurons. Lack of this factor results in a degeneration similar to that seen in Parkinson's disease. PITX3 is also important in eye developement; mutations of the PITX3 gene have been associated with a familial form of cataracts.