Host: Rabbit
Target Protein: Lamin B Receptor
IR: Immunogen Range:1-100/615
Clonality: Polyclonal
Isotype: IgG
Entrez Gene: 3930
Swiss Prot: Q14739
Source: KLH conjugated synthetic peptide derived from human Lamin B Receptor:1-100/615
Purification: affinity purified by Protein A
Storage: 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Background: Lamins are nuclear membrane proteins that serve to maintain specific cellular functions, such as DNA replication and chromatin organization. Lamin B receptor (LBR) is an integral protein of the nuclear envelope inner membrane. It is phosphorylated by CDC2 protein kinase in mitosis when the inner nuclear membrane breaks down into vesicles that dissociate from the lamina and the chromatin. It is phosphorylated by different protein kinases in interphase when the membrane is associated with these structures. The cleavage of lamins results in nuclear disregulation and cell death.
Size: 100ul
Concentration: 1mg/ml
Applications: WB=1:500-2000, ICC=1:25, Flow-Cyt=1ug/Test, ELISA=1:5000-10000
Cross Reactive Species: Mouse,Human (predicted: Rabbit,Horse,Cow,Rat)
For research use only. Not intended for diagnostic or therapeutic use.