Host: Rabbit

Target Protein: CREM

IR: Immunogen Range:251-361/361

Clonality: Polyclonal

Isotype: IgG

Entrez Gene: 1390

Swiss Prot: Q03060

Source: KLH conjugated synthetic peptide derived from human CREM:251-361/361 

Purification: affinity purified by Protein A

Storage: 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.

Background: CREM is a a bZIP transcription factor that binds to the cAMP responsive element found in many viral and cellular promoters. It is derived from a multiexonic gene that encodes both activators and antagonists of cAMP-inducible transcription by differential splicing. Splice variants with antagonistic function lack 2 glutamine-rich domains and block cAMP-induced transcription, whereas an isoform that includes these glutamine-rich domains is a transcriptional activator.