Host: Rabbit

Target Protein: Collagen VIII alpha 1

IR: Immunogen Range:641-744/744

Clonality: Polyclonal

Isotype: IgG

Entrez Gene: 1295

Swiss Prot: P27658

Source: KLH conjugated synthetic peptide derived from human Collagen VIII alpha 1:641-744/744 

Purification: affinity purified by Protein A

Storage: 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.

Background: Macromolecular component of the subendothelium. Major component of the Descemet's membrane (basement membrane) of corneal endothelial cells. Also component of the endothelia of blood vessels. Necessary for migration and proliferation of vascular smooth muscle cells and thus, has a potential role in the maintenance of vessel wall integrity and structure, in particular in artherogenesis. Vastatin, the C-terminal fragment comprising the NC1 domain, inhibits aortic endothelial cell proliferation and causes cell apoptosis.