Host: Rabbit
Target Protein: DIS3L2
IR: Immunogen Range:1-100/885
Clonality: Polyclonal
Isotype: IgG
Entrez Gene: 129563
Swiss Prot: Q8IYB7
Source: KLH conjugated synthetic peptide derived from human DIS3L2:1-100/885
Purification: affinity purified by Protein A
Storage: 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Background: The exosome is a multisubunit complex composed of several highly conserved subunits, some of which are 3’ to 5’ exoribonucleases. The complex is involved in a variety of cellular processes and is responsible for degrading unstable mRNAs that contain AU-rich (ARE) elements in their untranslated 3’ region. DIS3L2 (DIS3-like exonuclease 2) is an 885 amino acid protein that is thought to function as an exonuclease and may be required for the 3’ processing of pre-mRNA into mature mRNA. Defects or chromosomal translocations involving the gene encoding DIS3L2 may be associated with Marfanoid habitus, a genetic disorder characterized by abnormalities in the skeleton, eyes and cardiovascular system. DIS3L2 is expressed as five isoforms due to alternative splicing events.
Size: 50ul
Concentration: 1mg/ml
Applications: WB=1:500-2000, IHC-P=1:100-500, IHC-F=1:100-500, IF=1:50-200, Flow-Cyt=2ug/Test, ELISA=1:5000-10000
Cross Reactive Species: Mouse (predicted: Human,Rat,Dog,Pig,Cow,Sheep)
For research use only. Not intended for diagnostic or therapeutic use.