Host: Rabbit

Target Protein: TOP1MT

IR: Immunogen Range:366-488/601

Clonality: Polyclonal

Isotype: IgG

Entrez Gene: 116447

Swiss Prot: Q969P6

Source: KLH conjugated synthetic peptide derived from human TOP1mt:366-488/601 

Purification: affinity purified by Protein A

Storage: 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.

Background: This gene encodes a mitochondrial DNA topoisomerase that plays a role in the modification of DNA topology. The encoded protein is a type IB topoisomerase and catalyzes the transient breaking and rejoining of DNA to relieve tension and DNA supercoiling generated in the mitochondrial genome during replication and transcription. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, May 2012].