Host: Rabbit

Target Protein: PDE4A8

IR: Immunogen Range:201-300/886

Clonality: Polyclonal

Isotype: IgG

Entrez Gene: 5141

Swiss Prot: P27815

Source: KLH conjugated synthetic peptide derived from human PDE4A8:201-300/886 

Purification: affinity purified by Protein A

Storage: 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.

Background: The protein encoded by this gene belongs to the cyclicnucleotide phosphodiesterase (PDE) family, and PDE4 subfamily. ThisPDE hydrolyzes the second messenger, cAMP, which is a regulator andmediator of a number of cellular responses to extracellularsignals. Thus, by regulating the cellular concentration of cAMP,this protein plays a key role in many important physiologicalprocesses. Alternatively spliced transcript variants encodingdifferent isoforms have been described for this gene.[provided byRefSeq, Jul 2011].