bs-1439R [Primary Antibody]
Rabbit  Anti-JAK1  Polyclonal Antibody
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Host: Rabbit

Target Protein: JAK1

IR: Immunogen Range:901-1135/1135

Clonality: Polyclonal

Isotype: IgG

Entrez Gene: 3716

Swiss Prot: P23458

Source: KLH conjugated synthetic peptide derived from human JAK1:901-1135/1135 

Purification: affinity purified by Protein A

Storage: 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.

Background: Janus kinase 1 (JAK1) is a member of a new class of non-receptor protein-tyrosine kinases (PTK) characterized by the presence of a second phosphotransferase-related domain immediately N-terminal to the PTK domain. The second phosphotransferase domain bears all the hallmarks of a protein kinase, although its structure differs significantly from that of the PTK and threonine/serine kinase family members. JAK1 is a large, widely expressed membrane-associated phosphoprotein. It is involved in the interferon-alpha/beta and -gamma signal transduction pathways. The reciprocal interdependence between JAK1 and TYK2 activities in the interferon-alpha pathway, and between JAK1 and JAK2 in the interferon-gamma pathway, may reflect a requirement for these kinases in the correct assembly of interferon recpeptor complexes. These kinases couple cytokine ligand binding to tyrosine phosphorylation of various known signaling proteins and a unique family of transcription factors termed the signal transducers and activators of transcription, or STATs.

Size: 50ul

Concentration: 1mg/ml

Applications: WB=1:500-2000, IHC-F=1:100-500, IF=1:100-500, Flow-Cyt=1ug/Test, ELISA=1:5000-10000

Cross Reactive Species: Mouse,Human (predicted: Rat)

For research use only. Not intended for diagnostic or therapeutic use.

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