Host: Rabbit
Target Protein: 5 MethylCytosine
IR: Immunogen Range:
Clonality: Polyclonal
Isotype: IgG
Entrez Gene: 58366-64-6
Swiss Prot: N/A
Source: KLH conjugated 5 MethylCytosine:
Purification: affinity purified by Protein A
Storage: 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Background: Cytidine is a nucleoside formed by a cytosine attached to a ribose ring via a beta-N1-glycosidic bond. DNA is methylated on cytidines by DNA methylases (DNMTs)to generate 5-methylcytidine (5-mC), a potent epigenetics marker and regulator of gene expression. The reverse reaction (cytidine demethylation) starts with its oxidation to hydroxymethyl- (5-hmC), formyl- (5-fC), and carboxy- (5-caC) cytidine. Several enzymes, including the Tet family of proteins have been implicated in cytidine demethylation.
Size: 50ul
Concentration: 1mg/ml
Applications: Flow-Cyt=1ug/Test, ELISA=1:5000-10000
Cross Reactive Species: Human (predicted: 5 MethylCytosine)
For research use only. Not intended for diagnostic or therapeutic use.