Host: Rabbit
Target Protein: phospho-DOK1 (Tyr362)
IR: Immunogen Range:PI(p-Y)DE
Clonality: Polyclonal
Isotype: IgG
Entrez Gene: 1796
Swiss Prot: Q99704
Source: KLH conjugated Synthesised phosphopeptide derived from human DOK1 around the phosphorylation site of Tyr362:PI(p-Y)DE
Purification: affinity purified by Protein A
Storage: 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Background: Docking protein 1 is constitutively tyrosine phosphorylated in hematopoietic progenitors isolated from chronic myelogenous leukemia (CML) patients in the chronic phase. It may be a critical substrate for p210(bcr/abl), a chimeric protein whose presence is associated with CML. Docking protein 1 contains a putative pleckstrin homology domain at the amino terminus and ten PXXP SH3 recognition motifs. Docking protein 2 binds p120 (RasGAP) from CML cells. It has been postulated to play a role in mitogenic signaling.
Size: 100ul
Concentration: 1mg/ml
Applications: WB=1:500-2000, ELISA=1:5000-10000
Cross Reactive Species: Human (predicted: Mouse,Rat,Dog,Pig,Cow)
For research use only. Not intended for diagnostic or therapeutic use.