Host: Rabbit

Target Protein: phospho-DOK1 (Tyr362)

IR: Immunogen Range:PI(p-Y)DE

Clonality: Polyclonal

Isotype: IgG

Entrez Gene: 1796

Swiss Prot: Q99704

Source: KLH conjugated Synthesised phosphopeptide derived from human DOK1 around the phosphorylation site of Tyr362:PI(p-Y)DE 

Purification: affinity purified by Protein A

Storage: 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.

Background: Docking protein 1 is constitutively tyrosine phosphorylated in hematopoietic progenitors isolated from chronic myelogenous leukemia (CML) patients in the chronic phase. It may be a critical substrate for p210(bcr/abl), a chimeric protein whose presence is associated with CML. Docking protein 1 contains a putative pleckstrin homology domain at the amino terminus and ten PXXP SH3 recognition motifs. Docking protein 2 binds p120 (RasGAP) from CML cells. It has been postulated to play a role in mitogenic signaling.