Host: Rabbit

Target Protein: phospho-ILK-1 (Ser246)

IR: Immunogen Range:IF(p-S)HP

Clonality: Polyclonal

Isotype: IgG

Entrez Gene: 3611

Swiss Prot: Q13418

Source: KLH conjugated Synthesised phosphopeptide derived from human ILK-1 around the phosphorylation site of Ser246:IF(p-S)HP 

Purification: affinity purified by Protein A

Storage: 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.

Background: The ILK protein is important in different biological pathways such as cell adhesion, anchorage-dependent cell cycle progression, oncogenic transformation, and growth factor signaling. The kinase activity of ILK is low in non-activated cells; its activity is stimulated by cell-ECM interactions and by certain growth factors. 3 Negative regulation of ILK is mediated by two phosphatases: PTEN, a tumor suppressor lipid sphatase, and ILKAP, a PP2C protein phosphatase. In tumor cells that do not express PTEN protein, ILK is constitutively active.