Host: Rabbit
Target Protein: PRAK
IR: Immunogen Range:89-190/473
Clonality: Polyclonal
Isotype: IgG
Entrez Gene: 8550
Swiss Prot: Q8IW41
Source: KLH conjugated synthetic peptide derived from human MAPKAPK5/PRAK:89-190/473
Purification: affinity purified by Protein A
Storage: 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Background: The serine/threonine kinase PRAK is activated in response to cellular stress and proinflammatory cytokines, through its phosphorylation by MAP kinases including MAPK1/ERK, MAPK14/p38 alpha, and MAPK11/p38 beta. PRAK has been reported to have a putative tumor suppressor function by mediating senescence upon activation by p38 in response to oncogenic ras. It is thought that phosphorylation of p53 by PRAK following activation of p38 MAPK by ras plays an important role in ras induced senescence and tumor suppression.
Size: 200ul
Concentration: 1mg/ml
Applications: WB=1:500-2000, IHC-P=1:100-500, IHC-F=1:100-500, IF=1:100-500, Flow-Cyt=2ug/Test
Cross Reactive Species: Human,Mouse,Rat (predicted: Dog,Pig,Cow,Rabbit)
For research use only. Not intended for diagnostic or therapeutic use.