Host: Rabbit
Target Protein: phospho-PTPN6 (Tyr536)
IR: Immunogen Range:SE(p-Y)GN
Clonality: Polyclonal
Isotype: IgG
Entrez Gene: 5777
Swiss Prot: P29350
Source: KLH conjugated Synthesised phosphopeptide derived from human PTPN6 around the phosphorylation site of Tyr536:SE(p-Y)GN
Purification: affinity purified by Protein A
Storage: 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Background: The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. N-terminal part of this PTP contains two tandem Src homolog (SH2) domains, which act as protein phospho-tyrosine binding domains, and mediate the interaction of this PTP with its substrates. This PTP is expressed primarily in hematopoietic cells, and functions as an important regulator of multiple signaling pathways in hematopoietic cells. This PTP has been shown to interact with, and dephosphorylate a wide spectrum of phospho-proteins involved in hematopoietic cell signaling. Multiple alternatively spliced variants of this gene, which encode distinct isoforms, have been reported. [provided by RefSeq, Jul 2008]
Size: 200ul
Concentration: 1mg/ml
Applications: WB=1:500-2000, IHC-P=1:100-500, IHC-F=1:100-500, Flow-Cyt=2ug/test
Cross Reactive Species: Human (predicted: Dog,Horse)
For research use only. Not intended for diagnostic or therapeutic use.