Host: Rabbit

Target Protein: APH1a

IR: Immunogen Range:71-170/265

Clonality: Polyclonal

Isotype: IgG

Entrez Gene: 51107

Swiss Prot: Q96BI3

Source: KLH conjugated synthetic peptide derived from human APH1a:71-170/265 

Purification: affinity purified by Protein A

Storage: 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.

Background: APH1a is an essential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral proteins such as Notch receptors and APP (beta-amyloid precursor protein). It probably represents a stabilizing cofactor for the presenilin homodimer that promotes the formation of a stable complex. Belongs to the APH-1 family.