Host: Rabbit
Target Protein: APAF1(NT)
IR: Immunogen Range:13-80/1248
Clonality: Polyclonal
Isotype: IgG
Entrez Gene: 317
Swiss Prot: O14727
Source: KLH conjugated synthetic peptide derived from human Apaf-1:13-80/1248
Purification: affinity purified by Protein A
Storage: 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Background: This gene encodes a cytoplasmic protein that initiates apoptosis. This protein contains several copies of the WD-40 domain, a caspase recruitment domain (CARD), and an ATPase domain(NB-ARC). Upon binding cytochrome c and dATP, this protein forms an oligomeric apoptosome. The apoptosome binds and cleaves caspase 9 preproprotein, releasing its mature, activated form. Activated caspase 9 stimulates the subsequent caspase cascade that commits the cell to apoptosis. Alternative splicing results in several transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008].
Size: 200ul
Concentration: 1mg/ml
Applications: WB=1:500-2000, IHC-P=1:100-500, IHC-F=1:100-500, ICC=1:100, IF=1:100-500, Flow-Cyt=0.2ug/test, ELISA=1:5000-10000
Cross Reactive Species: Human,Mouse,Rat (predicted: Chicken,Dog,Cow,Horse)
For research use only. Not intended for diagnostic or therapeutic use.