Host: Rabbit
Target Protein: Klotho
IR: Immunogen Range:401-500/1012
Clonality: Polyclonal
Isotype: IgG
Entrez Gene: 9365
Swiss Prot: Q9UEF7
Source:
KLH conjugated synthetic peptide derived from human Klotho:401-500/1012
Purification: affinity purified by Protein A
Storage: 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Background: May have weak glycosidase activity towards glucuronylated steroids. However, it lacks essential active site Glu residues at positions 239 and 872, suggesting it may be inactive as a glycosidase in vivo. May be involved in the regulation of calcium and phosphorus homeostasis by inhibiting the synthesis of active vitamin D (By similarity). Essential factor for the specific interaction between FGF23 and FGFR1. The Klotho peptide generated by cleavage of the membrane-bound isoform may be an anti-aging circulating hormone which would extend life span by inhibiting insulin/IGF1 signaling.
Size: 100ul
Concentration: 1mg/ml
Applications: WB=1:200-2000, IHC-P=1:100-500, IHC-F=1:100-500, IF=1:100-500, ELISA=1:5000-10000
Cross Reactive Species: Rat,Mouse,Human (predicted: Rabbit,Horse,Cow,Pig,Dog)
For research use only. Not intended for diagnostic or therapeutic use.