ABCB5 Rabbit pAb (一抗) - WB | Bioss

bs-1604R

宠物抗体、农牧业/家禽抗体

ABCB5 Rabbit pAb

ATP结合蛋白家族5抗体

ABCB5alpha; ABCB5beta; EST422562; ABCB5_HUMAN; ABCB5; ABCB5 P-gp; P-glycoprotein ABCB5; ATP binding cassette subfamily B member 5; ATP-binding cassette, sub-family B (MDR/TAP), member 5; ATP-binding cassette protein

Rabbit

KLH conjugated synthetic peptide derived from human ABCB5: 841-883/1257

IgG

Liquid

affinity purified by Protein A

Polyclonal

89/138 kDa

125 kDa

1mg/ml

0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.

This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

ABCB5 belongs to the ATP-binding cassette (ABC) transporter superfamily of integral membrane proteins. These proteins participate in ATP-dependent transmembrane transport of structurally diverse molecules ranging from small ions, sugars, and peptides to more complex organic molecules (Chen et al., 2005 [PubMed 15760339]).[supplied by OMIM, Mar 2008]

ABCB5

ATP-binding cassette sub-family B member 5

Cell membrane; Multi-pass membrane protein.

Expressed by CD133-expressing progenitor cells among epidermal melanocytes (at protein level). Widely expressed with specific expression in pigment cells. Also expressed in several malignant tissues.

Belongs to the ABC transporter superfamily. ABCB family. Multidrug resistance exporter (TC 3.A.1.201) subfamily.
Contains 1 ABC transmembrane type-1 domain.
Contains 2 ABC transporter domains.

Plasma membrane transporter able to mediate efflux from cells of the rhodamine dye and of the therapeutic drug doxorubicin. Responsible for the resistance to doxorubicin of a subset of malignant melanomas.