CD36 Rabbit pAb (一抗) - WB,IP | Bioss

bs-1100R

CD36 Rabbit pAb

CD36抗体

BDPLT10; CHDS7; FAT; GP3B; GP4; GPIV; PASIV; SCARB3; GPIIIB; IV; PAS; PAS IV; PAS-4; CD36_HUMAN; CD36; Fatty acid translocase (FAT); Glycoprotein IIIb (GPIIIB); Leukocyte differentiation antigen CD36; Platelet collagen receptor; Platelet glycoprotein IV (GPIV); Thrombospondin receptor; CD36_MOUSE; CD36_RAT; Adipocyte membrane protein; Fatty acid translocase; Fatty acid transport protein; CD36 molecule (CD36 blood group); CD36 antigen (collagen type I receptor, thrombospondin receptor); CD36 molecule (thrombospondin receptor); scavenger receptor class B member 3; Platelet glycoprotein 4

Rabbit

KLH conjugated synthetic peptide derived from human CD36: 301-400/472

IgG

Liquid

affinity purified by Protein A

Polyclonal

52 kDa

77 kDa

1mg/ml

0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.

This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

CD36属一种多功能细胞膜受体，CD36参与长链脂肪酸的吸附和调节细胞凋亡残物的清理和巨噬细胞的吞噬作用， 属于一种抗蛋白酶血小板膜表面糖蛋白。
CD36 广泛在单核细胞、巨噬细胞、内皮层细胞、血小板、红细胞前板、脂肪细胞、肌肉细胞以及乳腺内皮层细胞中有不同的表达。CD36抗原是血小板反应素的配体，两者结合后产生抑制肿瘤血管生成的效应。

The protein encoded by this gene is the fourth major glycoprotein of the platelet surface and serves as a receptor for thrombospondin in platelets and various cell lines. Since thrombospondins are widely distributed proteins involved in a variety of adhesive processes, this protein may have important functions as a cell adhesion molecule. It binds to collagen, thrombospondin, anionic phospholipids and oxidized LDL. It directly mediates cytoadherence of Plasmodium falciparum parasitized erythrocytes and it binds long chain fatty acids and may function in the transport and/or as a regulator of fatty acid transport. Mutations in this gene cause platelet glycoprotein deficiency. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Feb 2014]

CD36

Platelet glycoprotein 4

Interacts with THBS1 and THBS2; the interactions mediate the THBS antiangiogenic activity.

Membrane; Multi-pass membrane protein.

Predominant in heart, intestine, spleen, fat, skeletal muscle, lower in testes.

N-glycosylated and O-glycosylated with a ratio of 2:1.

Defects in CD36 are the cause of platelet glycoprotein IV deficiency (PG4D)[MIM:608404]; also known as CD36 deficiency. Platelet glycoprotein IV deficiency can be divided into 2 subgroups. The type I phenotype is characterized by platelets and monocytes/macrophages exhibiting complete CD36 deficiency. The type II phenotype lacks the surface expression of CD36 in platelets, but expression in monocytes/macrophages is near normal.
Genetic variations in CD36 are associated with susceptibility to coronary heart disease type 7 (CHDS7) [MIM:610938].

Belongs to the CD36 family.

Seems to have numerous potential physiological functions. Binds to collagen, thrombospondin, anionic phospholipids and oxidized LDL. May function as a cell adhesion molecule. Directly mediates cytoadherence of Plasmodium falciparum parasitized erythrocytes. Binds long chain fatty acids and may function in the transport and/or as a regulator of fatty acid transport. Receptor for thombospondins, THBS1 AND THBS2, mediating their antiangiogenic effects.