SRSF10 | SRrp40/TASR Rabbit pAb (一抗) | Bioss

bs-13229R

宠物抗体、农牧业/家禽抗体

SRSF10 | SRrp40/TASR Rabbit pAb

富含丝氨酸/精氨酸重复结构蛋白抗体

SRS10_HUMAN; SRSF10; 40 kDa SR-repressor protein (SRrp40); FUS-interacting serine-arginine-rich protein 1; Splicing factor SRp38; Splicing factor, arginine/serine-rich 13A; TLS-associated protein with Ser-Arg repeats (TASR | TLS-associated protein with SR repeats); TLS-associated serine-arginine protein (TLS-associated SR protein); FUSIP1; FUSIP2; SFRS13A; TASR; SRS10_MOUSE; Neural-salient serine/arginine-rich protein; Neural-specific SR protein; Nssr; Srsf13a; serine and arginine rich splicing factor 10; FUS-interacting protein (serine-arginine rich) 2; FUS interacting protein (serine/arginine-rich) 1; neural-salient SR protein; serine/arginine-rich splicing factor 10; splicing factor, arginine/serine-rich 13; SR splicing factor 10; protein phosphatase 1, regulatory subunit 149

Rabbit

KLH conjugated synthetic peptide derived from human FUSIP1: 151-250/262

IgG

Liquid

affinity purified by Protein A

Polyclonal

31 kDa

31 kDa

1mg/ml

0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.

This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

FUSIP1 is a member of the Serine/Arginine (SR) family of splicing factors. Members of the SR family all contain one or more RNA recognition motifs (RRM) and an SR-rich domain. SR factors are not only essential for constitutive splicing but also regulate splicing in a concentration-dependent manner by influencing the selection of alternative splice sites. Expressed in a variety of tissues with low expression in kidney, liver and heart, FUSIP1 localizes to the cytoplasm and nuclear speckles. In its dephosphorylated form (occurring during M phase of the cell cycle), FUSIP1 functions as a potent general repressor of pre-mRNA splicing and can interact with U1 SnRNP 70. In its phosphorylated form, FUSIP1 interacts with Tra-2∫ and, together, they may cooperate in the regulation of splicing. Four isoforms exist for FUSIP1. In neurons, FUSIP1 isoforms may act to either positively or negatively regulate alternative splicing.

SRSF10

Serine/arginine-rich splicing factor 10

The phosphorylated but not the dephosphorylated form interacts with TRA2B/SFRS10. The dephosphorylated form interacts with SNRNP70. Isoform 1 and isoform 3 interact with FUS C-terminus.

Nucleus speckle. Cytoplasm.

Widely expressed.

Phosphorylated. Fully dephosphorylated in mitosis and partially dephosphorylated on heat shock.
Isoform 3 is phosphorylated on Ser-168.

Belongs to the splicing factor SR family.
Contains 1 RRM (RNA recognition motif) domain.

Splicing factor that in its dephosphorylated form acts as a general repressor of pre-mRNA splicing. Seems to interfere with the U1 snRNP 5'-splice recognition of SNRNP70. Required for splicing repression in M-phase cells and after heat shock. May be involved in regulation of alternative splicing in neurons, with isoform 1 acting as a positive and isoform 3 as a negative regulator.