GPX2 | GPx-GI Rabbit pAb (一抗) | Bioss

bs-13396R

宠物抗体、农牧业/家禽抗体

GPX2 | GPx-GI Rabbit pAb

谷胱甘肽过氧化酶2抗体

GI-GPx; GPRP; GPRP-2; GPx-2; GPx-GI; GSHPX-GI; GSHPx-2; GPX2_HUMAN; GPX2; Gastrointestinal glutathione peroxidase; Glutathione peroxidase-gastrointestinal (GPx-GI | GSHPx-GI); Glutathione peroxidase-related protein 2 (GPRP-2); Phospholipid hydroperoxide glutathione peroxidase GPX2; 1.11.1.9; GPX2_MOUSE; GPX2_RAT; glutathione peroxidase 2; glutathione peroxidase 2 (gastrointestinal); selenoprotein GPX2

Rabbit

KLH conjugated synthetic peptide derived from human GPX2/Glutathione Peroxidase 2: 41-140/190

IgG

Liquid

affinity purified by Protein A

Polyclonal

22 kDa

22 kDa

1mg/ml

0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.

This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

Glutathione peroxidase (GPx) enzymes are generally selenium-containing tetrameric glycoproteins that help prevent lipid peroxidation of cell membranes. GPx enzymes reduce lipid hydroperoxides to alcohols, and reduce free hydrogen peroxide to water. GPx members are among the few proteins known in higher vertebrates to contain selenocysteine, which occurs at the active site of glutathione peroxidase and is coded by the nonsense (stop) codon TGA. There are eight GPx homologs (GPx-1–8). GPx-1 plays an important role in the antioxidant defense of the vascular wall and neural cells in response to oxidative stress. GPx-2 is the major isoform in the lungs and its basal or inducible expression is dependent on Nrf2. GPx-3 is under regulation by hypoxic stress and the expression and deficiency of GPx-3 is associated with cardiovascular disease and stroke. GPx-5 is selenium-independent; it is bound to the acrosome of sperm, where it may protect sperm from premature acrosome reaction in the epididymis.

GPX2

Glutathione peroxidase 2

Homotetramer.

Cytoplasm. Mainly cytoplasmic.

Mostly in liver and gastrointestinal tract, not found in heart or kidney.

Belongs to the glutathione peroxidase family.

Could play a major role in protecting mammals from the toxicity of ingested organic hydroperoxides. Tert-butyl hydroperoxide, cumene hydroperoxide and linoleic acid hydroperoxide but not phosphatidycholine hydroperoxide, can act as acceptors.