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Rabbit Anti-CD31 antibody (bs-0195R)
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说明书: 50ul  100ul  200ul
50ul/980.00元
100ul/1680.00元
200ul/2480.00元
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产品编号 bs-0195R
英文名称 CD31
中文名称 血小板内皮细胞黏附分子1抗体
别    名 platelet endothelial cell adhesion molecule precursor-1; PECAM-1; PECAM1; Adhesion molecule; CD31 antigen; CD31 EndoCAM; Endocam; FLJ34100; FLJ58394; GPIIA; Pecam 1; PECA1_HUMAN; PECAM 1 CD31 EndoCAM; PECA1; Pecam1; Platelet endothelial cell adhesion molecule; Platelet/endothelial cell adhesion molecule 1; Adhesion molecule; Platelet/endothelial cell adhesion molecule.  
Specific References  (37)     |     bs-0195R has been referenced in 37 publications.
[IF=0] Tan et al. Controlled release of chitosan/heparin nanoparticle-delivered VEGF enhances regeneration of decellularized tissue-engineered scaffolds. (2011) Int.J.Nanomedicin. 6:929-42  IHC-P ;  Mouse.  
[IF=3.427] Gao et al. Common expression of stemness molecular markers and early cardiac transcription factors in human Wharton's jelly-derived mesenchymal stem cells and embryonic stem cells. (2013) Cell.Transplan. 22:1883-900  FCM ;  Human.  
[IF=5.94] Li et al. Repair of lipopolysaccharide-induced acute lung injury in mice by endothelial progenitor cells, alone and in combination with simvastatin. (2013) Ches. 144:876-86  IHC ;  Mouse.  
[IF=1.953] Ji et al. Sodium humate accelerates cutaneous wound healing by activating TGF-β/Smads signaling pathway in rats. (2016) Acta.Pharm.Sin.. 6:132-40  IHC-P ;  Rat.  
[IF=5.076] Brumm et al. Astrocytes Can Adopt Endothelial Cell Fates in a p53-Dependent Manner. (2017) Mol.Neurobiol. 54:4584-4596  ICC ;  Mouse.  
[IF=2.11] Lee et al. Chondrocyte-derived extracellular matrix suppresses pathogenesis of human pterygium epithelial cells by blocking the NF-κB signaling pathways. (2017) Mol.Vi. 22:1490-1502  WB ;  Human.  
[IF=.744] Tung et al. Fabrication of a reticular poly(lactide-co-glycolide) cylindrical scaffold for the in vitro development of microvascular networks. (2017) Sci.Technol.Adv.Mater. 18:163-171  FC ;  human.  
[IF=5.168] Wang et al. Targeting neurokinin-3 receptor: a novel anti-angiogenesis strategy for cancer treatment. (2017) Oncotarget. 8:40713-40723  IHC ;  Mouse.  
[IF=1.28] Wu et al. Overexpression and correlation of HIF-2α, VEGFA and EphA2 in residual hepatocellular carcinoma following high-intensity focused ultrasound treatment: Implications for tumor recurrence and progression. (2017) Exp.Ther.Me. 13:3529-3534  IHC-P ;  Mouse.  
[IF=2.34] Tang et al. Botulinum toxin A improves adipose tissue engraftment by promoting cell proliferation, adipogenesis and angiogenesis. (2017) Int.J.Mol.Med. 40:713-720  IF(IHC-F) ;  Rat.  
[IF=3.221] Connell,et al.Eliminating Regurgitation Reduces Fibrotic Remodeling of Functional Mitral Regurgitation Conditioned Valves.(2018) Annals of Biomedical Engineering. 46:670-683.  IHC-P ;  Porcine.  
[IF=2.314] Ma H et al. Interferon-γ facilitated adjuvant-induced arthritis at early stage. Scand J Immunol. 2019 Feb 9:e12757.  WB ;  Mouse.  
[IF=2.766] Takeoka Y et al. Regeneration of esophagus using a scaffold-free biomimetic structure created with bio-three-dimensional printing.PLoS One. 2019 Mar 8;14(3):e0211339.   IHC-P ;  Rat.  
[IF=5.57] Zhang C et al. Superparamagnetic iron oxide (SPIO) nanoparticles labeled endothelial progenitor cells (EPCs) administration inhibited heterotopic ossification in rats. Nanomedicine. 2019 Aug 7;21:102078.  IHC-P&WB ;  Rat.  
[IF=1.857] Taniguchi,et al.Scaffold-free trachea regeneration by tissue engineering with bio-3D printing.(2018) Interactive CardioVascular and Thoracic Surgery. 26:745-752.  IHC-P ;  Rat.  
[IF=4.58] Lu, Cong-Xiao, et al. "Sulfated polymannuroguluronate, a novel anti-AIDS drug candidate, inhibits HIV-1 Tat-induced angiogenesis in Kaposi's sarcoma cells." Biochemical pharmacology 74.9 (2007): 1330-1339.  Human.  
[IF=2.51] Gao, Qian, et al. "Expression pattern of embryonic stem cell markers in DFAT cells and ADSCs." Molecular biology reports 39.5 (2012): 5791-5804.  IF(ICC) ;  Rat.  
[IF=3.73] Lv, Fang, et al. "Repeated Abortion Affects Subsequent Pregnancy Outcomes in BALB/c Mice." PloS one 7.10 (2012): e48384.  IHC-P ;  Mouse.  
[IF=7.6] Zhang, Hong, et al. "Dual-delivery of VEGF and PDGF by double-layered electrospun membranes for blood vessel regeneration." Biomaterials (2013).  Rat.  
[IF=7.6] Han, Fengxuan, et al. "Performance of a multilayered small-diameter vascular scaffold dual-loaded with VEGF and PDGF." Biomaterials (2013).  Rabbit.  
[IF=1.93] Lee, Hye Sook, Ji Hyun Lee, and Jae Wook Yang. "Effect of porcine chondrocyte derived extracellular matrix on the pterygium in mouse model." Graefes Archive for Clinical and Experimental Ophthalmology (2014) 1-10.  IHC-P ;  Mouse.  
[IF=3.17] Liu, Yang, et al. "Amelioration of Stroke-Induced Neurological Deficiency by Lyophilized Powder of Catapol and Puerarin." International Journal of Biological Sciences 10.4 (2014): 448-456.  IHC-P ;  Mouse.  
[IF=7.6] Choi, Byung Hyune, et al. "Inhibition of blood vessel formation by a chondrocyte-derived extracellular matrix." Biomaterials (2014).  IHC-P ;  Rabbit.  
[IF=1.93] Lee, Hye Sook, et al. "Anti-neovascular effect of chondrocyte-derived extracellular matrix on corneal alkaline burns in rabbits." Graefes Archive for Clinical and Experimental Ophthalmology (2014): 1-11.  WB ;  Rabbit.  
[IF=3.53] Lee, Tao-Chen, et al. "Comparison of Surface Markers between Human and Rabbit Mesenchymal Stem Cells." PLOS ONE 9.11 (2014): e111390.  FCM ;  Rabbit.  
[IF=2.81] Sun, Wei, et al. "Adipose-Derived Stem Cells Alleviate Radiation-Induced Muscular Fibrosis by Suppressing the Expression of TGF-1." (2015) Stem Cells International.  FCM ;  Rabbit.  
[IF=2.47] Struecker, B., et al. "Implantation of a Tissue-Engineered Neo-Bile Duct in Domestic Pigs." European Surgical Research 56.1-2 (2015): 61-75.  IHC-P ;  Pig.  
[IF=2.04] Karaca, T., et al. "Effects of hyperthyroidism on expression of vascular endothelial growth factor (VEGF) and apoptosis in fetal adrenal glands."European Journal of Histochemistry 59.4 (2015).  IHC-P ;  Rat.  
[IF=2.54] Wang, Li, et al. "Ghrelin inhibits atherosclerotic plaque angiogenesis and promotes plaque stability in a rabbit atherosclerotic model." Peptides (2017).  IHC-P ;  Rabbit.  
[IF=2.2] Zhang, Jue-yu, et al. "Local application of paeonol prevents early restenosis: a study with a rabbit vein graft model." Journal of Surgical Research (2016).  WB ;  Rabbit.  
[IF=3.04] Korkmaz, H. Ibrahim, et al. "Neutrophil Extracellular Traps Coincide with a Pro‐coagulant Status of Microcirculatory Endothelium in Burn Wounds." Wound Repair and Regeneration (2017).  IHC-P ;  Rat.  
[IF=2.8] Kong, Hyun Sun, et al. "Effect of treatment with angiopoietin-2 and vascular endothelial growth factor on the quality of xenografted bovine ovarian tissue in mice." PloS one 12.9 (2017): e0184546.  IHC-P ;  Bovine.  
[IF=1.719] Saribas GS et al. Effects of uterus derived mesenchymal stem cells and their exosomes on asherman's syndrome. Acta Histochem. 2019 Nov 24:151465.  IHC-P ;  Rat.  
[IF=0] Taniguchi D et al. Human lung microvascular endothelial cells as potential alternatives to human umbilical vein endothelial cells in bio-3D-printed trachea-like structures. Tissue and Cell,2020, 63, 101321.  IHC-P ;  Human.  
[IF=4.011] Zhou C et al. Combining transcatheter arterial embolization with iodized oil containing Apatinib inhibits HCC growth and metastasis. Sci Rep. 2020 Feb 19;10(1):2964.   ICC ;  Human.  
[IF=4.627] Jin S et al. Conditioned medium derived from FGF-2-modified GMSCs enhances migration and angiogenesis of human umbilical vein endothelial cells. Stem Cell Res Ther. 2020 Feb 18;11(1):68.  IHC-P ;  Mouse.  
[IF=.181] Li S et al. The Effect of YiQiFuMai on Ischemic Heart Failure by Improve Myocardial Microcirculation and Increase eNOS and VEGF Expression. International Journal of Clinical Medicine,2020 11, 84-100.  IHC-P ;  Rabbit.  
研究领域 肿瘤  心血管  细胞生物  免疫学  信号转导  干细胞  细胞粘附分子  细胞表面分子  糖蛋白  细胞类型标志物  血管内皮细胞  t-淋巴细胞  内皮细胞  
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Human, Mouse, Rat, Dog, Pig, Cow, Rabbit, Sheep, 
产品应用 WB=1:500-2000 ELISA=1:500-1000 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 78kDa
细胞定位 细胞膜 
性    状 Liquid
浓    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human CD31:681-738/738 <Cytoplasmic>
亚    型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMed PubMed
产品介绍 This protein is a cell adhesion molecule expressed on platelets and at endothelial cell intercellular junctions. Type I membrane protein. SIZE: 738 amino acids; 82536 Da. SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein. TISSUE SPECIFICITY: Long isoform predominates all tissues examined, isoform Delta12 was detected only in trachea and isoform Delta14-15 only in lung, isoform Delta14 was detected in all tissues examined with the strongest expression in heart. PTM: Phosphorylated on Ser and Tyr residues after cellular activation. SIMILARITY: Contains 6 Ig-like C2-type (immunoglobulin-like) domains.
CD31, also known as platelet endothelial cell adhesion molecule 1 (PECAM1), is a type I integral membrane glycoprotein and a member of the immunoglobulin superfamily of cell surface receptors. It is found on the surface of platelets, monocytes, neutrophils, and some types of T-cells, and makes up a large portion of endothelial cell intercellular junctions. CD31 is implicated in several functions, including transendothelial migration of leukocytes, angiogenesis, and integrin activation. Tyr-690 plays a critical role in leukocyte transendothelial migration (TEM) and is required for efficient trafficking of CD31 to and from the lateral border recycling compartment (LBRC) and is also essential for the LBRC membrane to be targeted around migrating leukocytes. CD31 prevents phagocyte ingestion of closely apposed viable cells by transmitting 'detachment' signals, and changes function on apoptosis, promoting tethering of dying cells to phagocytes (the encounter of a viable cell with a phagocyte via the homophilic interaction of CD31 on both cell surfaces leads to the viable cell's active repulsion from the phagocyte. During apoptosis, the inside-out signaling of CD31 is somehow disabled so that the apoptotic cell does not actively reject the phagocyte anymore. The lack of this repulsion signal together with the interaction of the eat-me signals and their respective receptors causes the attachment of the apoptotic cell to the phagocyte, thus triggering the process of engulfment). CD31 has been used to measure angiogenesis in association with tumor recurrence. Other studies have also indicated that CD31 and CD34 can be used as markers for myeloid progenitor cells and recognize different subsets of myeloid leukemia infiltrates (granular sarcomas).

Function:
Induces susceptibility to atherosclerosis (By similarity). Cell adhesion molecule which is required for leukocyte transendothelial migration (TEM) under most inflammatory conditions. Tyr-690 plays a critical role in TEM and is required for efficient trafficking of PECAM1 to and from the lateral border recycling compartment (LBRC) and is also essential for the LBRC membrane to be targeted around migrating leukocytes. Prevents phagocyte ingestion of closely apposed viable cells by transmitting 'detachment' signals, and changes function on apoptosis, promoting tethering of dying cells to phagocytes (the encounter of a viable cell with a phagocyte via the homophilic interaction of PECAM1 on both cell surfaces leads to the viable cell's active repulsion from the phagocyte. During apoptosis, the inside-out signaling of PECAM1 is somehow disabled so that the apoptotic cell does not actively reject the phagocyte anymore. The lack of this repulsion signal together with the interaction of the eat-me signals and their respective receptors causes the attachment of the apoptotic cell to the phagocyte, thus triggering the process of engulfment). Isoform Delta15 is unable to protect against apoptosis. Modulates BDKRB2 activation. Regulates bradykinin- and hyperosmotic shock-induced ERK1/2 activation in human umbilical cord vein cells (HUVEC).

Subunit:
Interacts with PTPN11; Tyr-713 is critical for PTPN11 recruitment. Forms a complex with BDKRB2 and GNAQ. Interacts with BDKRB2 and GNAQ.

Subcellular Location:
Isoform Long: Membrane; Single-pass type I membrane protein. Cell junction. Note=Localizes to the lateral border recycling compartment (LBRC) and recycles from the LBRC to the junction in resting endothelial cells.
Isoform Delta15: Cell junction. Note=Localizes to the lateral border recycling compartment (LBRC) and recycles from the LBRC to the junction in resting endothelial cells.

Tissue Specificity:
Expressed on platelets and leukocytes and is primarily concentrated at the borders between endothelial cells. Isoform Long predominates in all tissues examined. Isoform Delta12 is detected only in trachea. Isoform Delta14-15 is only detected in lung. Isoform Delta14 is detected in all tissues examined with the strongest expression in heart. Isoform Delta15 is expressed in brain, testis, ovary, cell surface of platelets, human umbilical vein endothelial cells (HUVECs), Jurkat T-cell leukemia, human erythroleukemia (HEL) and U937 histiocytic lymphoma cell lines (at protein level).

Post-translational modifications:
Phosphorylated on Ser and Tyr residues after cellular activation. Phosphorylated on tyrosine residues by FER and FES in response to FCER1 activation (By similarity). In endothelial cells Fyn mediates mechanical-force (stretch or pull) induced tyrosine phosphorylation.

Similarity:
Contains 6 Ig-like C2-type (immunoglobulin-like) domains.

SWISS:
P16284

Gene ID:
5175

Database links:

Entrez Gene: 5175 Human

Entrez Gene: 18613 Mouse

Omim: 173445 Human

SwissProt: P16284 Human

SwissProt: Q08481 Mouse

Unigene: 376675 Human

Unigene: 514412 Human

Unigene: 343951 Mouse



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

血小板内皮细胞黏附分子-1 ( Platelet/ endothelial cell adhesion molecule, PECAM-1)在血小板、内皮细胞、单核细胞、嗜中性细胞及某些T细胞亚群上表达的质膜糖蛋白,属于免疫球蛋白超基因家族成员,在细胞外结构域中有6个C2亚类免疫球蛋白样保守性同原单位。在炎症应答中起作用。
产品图片
Sample: U937 (human)Cell Lysate at 40 ug
Primary: Anti- CD31 (bs-0195R) at 1/300 dilution
Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
Predicted band size: 78 kD
Observed band size: 135kD
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