产品中心-北京博奥森生物技术有限公司

产品编号	bs-0124R
英文名称	Calcitonin receptor
中文名称	降钙素受体抗体
别名	Calcitonin receptor precursor; Calcr; CRT; CT R; CTR; CTR1; CALCR_MOUSE; CT-R; CALCR_HUMAN.
	Specific References (11) \| bs-0124R has been referenced in 11 publications. [IF=14.903] Tong Gao. et al. Macrophage-camouflaged epigenetic nanoinducers enhance chemoimmunotherapy in triple negative breast cancer. ACTA PHARM SIN B. 2022 Nov;: IF ; Mouse. PubMed:10.1016/j.apsb.2022.11.018 [IF=13.116] Yanmei He. et al. A combinational chemo-immune therapy using an enzyme-sensitive nanoplatform for dual-drug delivery to specific sites by cascade targeting. Sci Adv. 2021 Feb;7(6):eaba0776 IF ; Mouse. PubMed:33547067 [IF=12.13] Tian Zhang. et al. Supramolecular Tadalafil Nanovaccine for Cancer Immunotherapy by Alleviating Myeloid-Derived Suppressor Cells and Heightening Immunogenicity. 2021 May 13 IHC ; Mouse. PubMed:10.1002/smtd.202100115 [IF=8.947] Zhen-Han Feng. et al. A combination strategy based on an Au nanorod/doxorubicin gel via mild photothermal therapy combined with antigen-capturing liposomes and anti-PD-L1 agent promote a positive shift in the cancer-immunity cycle. Acta Biomater. 2021 Oct;: IF ; Mouse. PubMed:34619371 [IF=6.6] Jessika Appelt. et al. Mice Lacking the Calcitonin Receptor Do Not Display Improved Bone Healing. Cells-Basel. 2021 Sep;10(9):2304 IF ; mouse. PubMed:34571953 [IF=5.458] Tazio Maleitzke. et al. The calcitonin receptor protects against bone loss and excessive inflammation in collagen antibody-induced arthritis. Iscience. 2022 Jan;25:103689 IHC ; Mouse. PubMed:35036874 [IF=3.97] Tsukamoto, Manabu, et al. "Elcatonin prevents bone loss caused by skeletal unloading by inhibiting preosteoclast fusion through the unloading-induced high expression of calcitonin receptors in bone marrow cells." Bone (2016). IHC-P ; Mouse. PubMed:26851124 [IF=2.46] Su, Jiansheng, et al. "Ibuprofen Rescues Abnormalities in Periodontal Tissues in Conditional Presenilin 1 and Presenilin 2 Double Knockout Mice."International Journal of Molecular Sciences?14.9 (2013): 18457-18469. IHC-P ; Mouse. PubMed:24018889 [IF=2.241] Bobek J et al. Onset of calciotropic receptors during the initiation of mandibular/alveolar bone formation. Ann Anat. 2019 Oct 12;227:151427. IHC-P ; Mouse. PubMed:31614180 [IF=0.23] Zhou, Zhen, et al. "The effects of ZJXG decoction on the serum CT levels and the expressions of CTR and Cbfα1 in callus of femur fracture rats." Biomedical Research 27.3 (2016): 762-768. IHC-P ; Rat. PubMed:ISSN0970-938X [IF=0] Wenhuan Chai. et al. Visualizing Cathepsin K-Cre Expression at the Single-Cell Level with GFP Reporters. JBMR Plus. 2022 Dec;:e10706 IF ; Mouse. PubMed:36699636
研究领域	肿瘤免疫学神经生物学信号转导细胞膜受体 G蛋白偶联受体
抗体来源	Rabbit
克隆类型	Polyclonal
交叉反应	Rat (predicted: Mouse)
产品应用	IHC-P=1:100-500, IHC-F=1:100-500, ICC=1:100-500, IF=1:100-500, ELISA=1:5000-10000 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
理论分子量	53kDa
细胞定位	细胞膜
性状	Liquid
浓度	1mg/ml
免疫原	KLH conjugated synthetic peptide derived from mouse Calcitonin receptor: 31-120/516 <Extracellular>
亚型	IgG
纯化方法	affinity purified by Protein A
缓冲液	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
注意事项	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
产品介绍	This gene encodes a high affinity receptor for the peptide hormone calcitonin and belongs to a subfamily of seven transmembrane-spanning G protein-coupled receptors. The encoded protein is involved in maintaining calcium homeostasis and in regulating osteoclast-mediated bone resorption. Polymorphisms in this gene have been associated with variations in bone mineral density and onset of osteoporosis. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2009] Function: This is a receptor for calcitonin. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. The calcitonin receptor is thought to couple to the heterotrimeric guanosine triphosphate-binding protein that is sensitive to cholera toxin. Subunit: Interacts with GPRASP2. Subcellular Location: Cell membrane; Multi-pass membrane protein. Similarity: Belongs to the G-protein coupled receptor 2 family. SWISS: P32214 Gene ID: 12311 Database links: Entrez Gene: 799 Human Entrez Gene: 12311 Mouse Entrez Gene: 116506 Rat Omim: 114131 Human SwissProt: P30988 Human SwissProt: Q60755 Mouse SwissProt: P32214 Rat Unigene: 489127 Human Unigene: 4642 Mouse Unigene: 10062 Rat 降钙素受体（Calcitonin receptor,CT-R)是G蛋白偶联受体，有两种受体亚型，CT-R可与多种配体结合，如CGRP、Amylin、Am等。CT-R在破骨细胞中含量最高，也存在于肾等多种器官组织内。
产品图片	Paraformaldehyde-fixed, paraffin embedded (Rat testis); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (CALCR) Polyclonal Antibody, Unconjugated (bs-0124R) at 1:500 overnight at 4°C, followed by a conjugated secondary (sp-0023) for 20 minutes and DAB staining.

	免疫组化常用试剂
	免疫印迹常用试剂
	各种标记二抗

	1、抗体溶解方法
	2、抗体修复方式
	3、常用试剂的配制
	4、免疫组化操作步骤
	5、免疫组化问题解答
	6、Western Blotting 操作步骤
	7、Western Blotting 问题解答
	8、关于肽链的设计
	9、多肽的溶解与保存
	10、酶标抗体效价测定程序

	Alexa Fluor 350 标记
	Alexa Fluor 488 标记
	Alexa Fluor 555 标记
	Alexa Fluor 594 标记
	Alexa Fluor 647 标记
	AP 标记
	APC 标记
	Biotin 标记
	Cy3 标记
	Cy5 标记
	Cy5.5 标记
	Cy7 标记
	FITC 标记
	Gold 标记
	HRP 标记
	PE 标记
	PE-Cy3 标记
	PE-CY5 标记
	PE-CY5.5 标记
	PE-CY7 标记
	RBITC 标记