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Rabbit Anti-IL-6 antibody (bs-0782R)
~~~促销,代码KT2401~~~
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说明书: 50ul  100ul  200ul
50ul/1180.00元
100ul/1980.00元
200ul/2800.00元
大包装/询价

产品编号 bs-0782R
英文名称 IL-6
中文名称 白介素6抗体
别    名 Interleukin BSF 2; B cell differentiation factor; B cell stimulatory factor 2; BSF 2; BSF2; CDF; CTL differentiation factor; Cytotoxic T cell differentiation factor; Hepatocyte stimulating factor; HGF; HPGF; HSF; Hybridoma growth factor; Hybridoma plasmacytoma growth factor; IFNB2; IL 6; IL6 protein; Interferon beta 2; Interleukin 6 (interferon beta 2); Interleukin 6; Interleukin-6; Interleukin6; IL6_HUMAN.  
Specific References  (110)     |     bs-0782R has been referenced in 110 publications.
[IF=24.897] Yuan, Xulei. et al. Systemic antibiotics increase microbiota pathogenicity and oral bone loss. INT J ORAL SCI. 2023 Jan;15(1):1-14  IHC ;  Mouse.  
[IF=17.521] Huan Lei. et al. A Combination Therapy Using Electrical Stimulation and Adaptive, Conductive Hydrogels Loaded with Self-Assembled Nanogels Incorporating Short Interfering RNA Promotes the Repair of Diabetic Chronic Wounds. Advanced Science. 2022 Sep;:2201425  IF ;  Rat.  
[IF=16.907] Yunxiang Sun. et al. Spontaneous formation of β-sheet nano-barrels during the early aggregation of Alzheimer’s amyloid beta. Nano Today. 2021 Jun;38:101125  WB ;  Mouse.  
[IF=16.744] Lubin Zhou. et al. A self-pumping dressing with in situ modification of non-woven fabric for promoting diabetic wound healing. CHEM ENG J. 2022 Dec;:141108  IHC ;  Rat.  
[IF=14.593] Ya-nan Fu. et al. Spatiotemporally dynamic therapy with shape-adaptive drug-gel for the improvement of tissue regeneration with ordered structure. Bioact Mater. 2021 Jun;:  IHC ;  Rat.  
[IF=13.273] Fangyu Qiao. et al. 4-Octyl itaconate modified demineralized bone matrix scaffold improves bone repair by regulating early inflammation. Chem Eng J. 2021 Dec;425:131490  WB,IF ;  Rat.  
[IF=13.273] Xuefang Hao. et al. Biomimetic and responsive nanoparticles loading JQ1 for dual-targeting treatment of vascular restenosis via multiple actions. Chem Eng J. 2021 Nov;:133452  WB ;  Mouse.  
[IF=13.116] Yan Li. et al. Injectable hydrogel with MSNs/microRNA-21-5p delivery enables both immunomodification and enhanced angiogenesis for myocardial infarction therapy in pigs. Sci Adv. 2021 Feb;7(9):eabd6740  WB ;  Pig.  
[IF=12.121] Haile Liu. et al. Catalytically potent and selective clusterzymes for modulation of neuroinflammation through single-atom substitutions. Nat Commun. 2021 Jan;12(1):1-14  IHC ;  Mouse.  
[IF=11.092] Fangyu Qiao. et al. Hybrid Cell Membrane-Functionalized Matrixes for Modulating Inflammatory Microenvironment and Improving Bone Defect Repair. ADV HEALTHC MATER. 2023 Apr;:2203047  IF ;  Rat.  
[IF=10.633] Jie Li. et al. Hydrogel delivery of DNase I and liposomal vancomycin to eradicate fracture-related methicillin-resistant staphylococcus aureus infection and support osteoporotic fracture healing. ACTA BIOMATER. 2023 Apr;:  IHC ;  Rat.  
[IF=10.383] Chaowei Li. et al. Cohesion Design-Led Tough Sealants with Controllably Dissolvable Properties. ACS APPL MATER INTER. 2022;14(30):34415–34426  ELISA ;  Rat.  
[IF=10.269] Zhang, Ziyuan. et al. Peptide nanotube loaded with a STING agonist, c-di-GMP, enhance cancer immunotherapy against melanoma. NANO RES. 2022 Nov;:1-10  IF ;  Mouse.  
[IF=9.811] Nicholas Andrikopoulos. et al. Inhibition of Amyloid Aggregation and Toxicity with Janus Iron Oxide Nanoparticles. Chem Mater. 2021;XXXX(XXX):XXX-XXX  WB ;  Mouse.  
[IF=9.587] Lee Hyun Ju. et al. Myeloid cells protect corneal nerves against sterile injury through negative-feedback regulation of TLR2–IL-6 axis. J NEUROINFLAMM. 2023 Dec;20(1):1-15  IF ;  Mouse.  
[IF=9.587] Bühler Melanie. et al. IFNAR signaling of neuroectodermal cells is essential for the survival of C57BL/6 mice infected with Theiler’s murine encephalomyelitis virus. J NEUROINFLAMM. 2023 Dec;20(1):1-19  IHC ;  Mouse.  
[IF=9.304] Sher Bahadur Poudel. et al. Sexual dimorphic impact of adult-onset somatopause on life span and age-induced osteoarthritis. 2021 Jul 09  IHC ;  Mouse.  
[IF=9.229] Jiarong Yang. et al. Mitigation Effects of Selenium Nanoparticles on Depression-Like Behavior Induced by Fluoride in Mice via the JAK2-STAT3 Pathway. Acs Appl Mater Inter. 2022;14(3):3685–3700  WB ;  Mouse.  
[IF=8.786] Xiaoyu Guo. et al. Effects of Boric Acid Gel on Vaginal Candida albicans Infections and the Local Immune System in Mice. FRONT IMMUNOL. 2022; 13: 950215  IHC ;  Mouse.  
[IF=8.579] Xin Chen. et al. Aurka loss in CD19+ B cells promotes megakaryocytopoiesis via IL-6/STAT3 signaling-mediated thrombopoietin production. Theranostics. 2021; 11(10): 4655–4671  IF ;  Mouse.  
[IF=8.579] Siqi Ying. et al. Low-intensity Pulsed Ultrasound regulates alveolar bone homeostasis in experimental Periodontitis by diminishing Oxidative Stress. Theranostics. 2020; 10(21): 9789–9807  IHC ;  Mouse, Rat.  
[IF=7.419] Changlong Fu. et al. Achyranthes bidentata polysaccharides alleviate endoplasmic reticulum stress in osteoarthritis via lncRNA NEAT1/miR-377-3p pathway. BIOMED PHARMACOTHER. 2022 Oct;154:113551  WB ;  Mouse.  
[IF=7.328] Dongdong Yao. et al. Matrix stiffness regulates bone repair by modulating 12-lipoxygenase-mediated early inflammation. Mat Sci Eng C-Mater. 2021 Sep;128:112359  WB,IF,IHC ;  Rat.  
[IF=7.324] Yongbo Kang. et al. A Novel Synbiotic Alleviates Autoimmune Hepatitis by Modulating the Gut Microbiota-Liver Axis and Inhibiting the Hepatic TLR4/NF-κB/NLRP3 Signaling Pathway. MSYSTEMS. 2023 Feb 16  IHC ;  Mouse.  
[IF=7.242] Yan Li. et al. Salicylic acid-based nanomedicine with self-immunomodulatory activity facilitates microRNA therapy for metabolic skeletal disorders. Acta Biomater. 2021 Jun;:  WB ;  Mouse.  
[IF=7.169] Xie, Zhan. et al. JP1, a polypeptide specifically targeting integrin αVβ3, ameliorates choroidal neovascularization and diabetic retinopathy in mice. ACTA PHARMACOL SIN. 2022 Oct;:1-16  IHC, WB ;  Mouse.  
[IF=7.129] Yunhui Xia. et al. Embryonic 6:2 FTOH exposure causes reproductive toxicity by disrupting the formation of the blood-testis barrier in offspring mice. ECOTOX ENVIRON SAFE. 2023 Jan;250:114497  IF ;  Mouse.  
[IF=7.086] Quan-Kuo He. et al. Captan exposure disrupts ovarian homeostasis and affects oocytes quality via mitochondrial dysfunction induced apoptosis. Chemosphere. 2022 Jan;286:131625  WB ;  Mouse.  
[IF=6.922] Zhen-Ni Liu. et al. CD73 Attenuates Alcohol-Induced Liver Injury and Inflammation via Blocking TLR4/MyD88/NF-κB Signaling Pathway. J Inflamm Res. 2022 Jan;15:53-70  IHC ;  Mouse.  
[IF=6.656] Hongya Guo. et al. Gua Lou Er Chen Decoction Attenuates Atherosclerosis by Reducing Proteoglycans Accumulation and Inflammation. PHYTOMEDICINE. 2023 Apr;:154811  WB ;  Mouse.  
研究领域 免疫学  
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Human, Mouse, Rat, 
产品应用 WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 (石蜡切片需做抗原修复)
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
理论分子量 23kDa
细胞定位 分泌型蛋白 
性    状 Liquid
浓    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from mouse IL-6: 111-150/211 
亚    型 IgG
纯化方法 affinity purified by Protein A
缓 冲 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
注意事项 This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed PubMed
产品介绍 This gene encodes a cytokine that functions in inflammation and the maturation of B cells. In addition, the encoded protein has been shown to be an endogenous pyrogen capable of inducing fever in people with autoimmune diseases or infections. The protein is primarily produced at sites of acute and chronic inflammation, where it is secreted into the serum and induces a transcriptional inflammatory response through interleukin 6 receptor, alpha. The functioning of this gene is implicated in a wide variety of inflammation-associated disease states, including suspectibility to diabetes mellitus and systemic juvenile rheumatoid arthritis. [provided by RefSeq, Jun 2011].

Function:
Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. It induces myeloma and plasmacytoma growth and induces nerve cells differentiation Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance.

Subcellular Location:
Secreted.

Post-translational modifications:
N- and O-glycosylated.

DISEASE:
Genetic variations in IL6 are associated with susceptibility to rheumatoid arthritis systemic juvenile (RASJ) [MIM:604302]. An inflammatory articular disorder with systemic-onset beginning before the age of 16. It represents a subgroup of juvenile arthritis associated with severe extraarticular features and occasionally fatal complications. During active phases of the disorder, patients display a typical daily spiking fever, an evanescent macular rash, lymphadenopathy, hepatosplenomegaly, serositis, myalgia and arthritis.
Note=A IL6 promoter polymorphism is associated with a lifetime risk of development of Kaposi sarcoma in HIV-infected men.

Similarity:
Belongs to the IL-6 superfamily.

SWISS:
P05231

Gene ID:
3569

Database links:

Entrez Gene: 3569 Human

Entrez Gene: 16193 Mouse

Entrez Gene: 24498 Rat

Omim: 147620 Human

SwissProt: P05231 Human

SwissProt: P08505 Mouse

SwissProt: P20607 Rat

Unigene: 654458 Human

Unigene: 1019 Mouse

Unigene: 9873 Rat



生长因子和激素( Growth Factor and Hormones)
白介素-6是一种多功能细胞因子,既可由淋巴细胞产生,也能由非淋巴细胞合成。在体内免疫反应调节、血细胞的增生、防御机制和急性期反应中起重要作用。
IL6是一种糖蛋白,它既可诱导急性期时相关蛋白的产生,也是β细胞终末分化并分泌抗体的必需因子。
产品图片
Sample: Heart (rat)l Lysate at 40 ug
Primary: Anti- IL-6 (bs-0782R) at 1/300 dilution
Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
Predicted band size: 23 kD
Observed band size: 23kD
Tissue/cell: mouse lung tissue; 4% Paraformaldehyde-fixed and paraffin-embedded;
Antigen retrieval: citrate buffer ( 0.01M, pH 6.0 ), Boiling bathing for 15min; Block endogenous peroxidase by 3% Hydrogen peroxide for 30min; Blocking buffer (normal goat serum,C-0005) at 37℃ for 20 min;
Incubation: Anti-IL-6(mo, rat) Polyclonal Antibody, Unconjugated(bs-0782R) 1:200, overnight at 4°C, followed by conjugation to the secondary antibody(SP-0023) and DAB(C-0010) staining
Tissue/cell: rat liver tissue; 4% Paraformaldehyde-fixed and paraffin-embedded;
Antigen retrieval: citrate buffer ( 0.01M, pH 6.0 ), Boiling bathing for 15min; Block endogenous peroxidase by 3% Hydrogen peroxide for 30min; Blocking buffer (normal goat serum,C-0005) at 37℃ for 20 min;
Incubation: Anti-IL-6(mo, rat) Polyclonal Antibody, Unconjugated(bs-0782R) 1:200, overnight at 4°C, followed by conjugation to the secondary antibody(SP-0023) and DAB(C-0010) staining
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