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Rabbit Anti-IRS3  antibody (bs-0186R)
~~~促销,代码KX240301~~~
~~~促销,代码KX240302~~~
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说明书: 50ul  100ul  200ul
50ul/1180.00元
100ul/1980.00元
200ul/2800.00元
大包装/询价

产品编号 bs-0186R
英文名称 IRS3
中文名称 胰岛素受体底物-3抗体
别    名 IRS1--Insulin receptor substrate-3; IRS3; IRS-3; IRS3.  
Specific References  (1)     |     bs-0186R has been referenced in 1 publications.
[IF=3.996] Yanhan Ma. et al. Effect of Interleukin-1β on Gene Expression Signatures in Schwann Cells Associated with Neuropathic Pain. 2021 Jul 15  IHC ;  Rat.  
研究领域 细胞生物  神经生物学  信号转导  激酶和磷酸酶  糖尿病  内分泌病  结合蛋白  
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Mouse,Rat,Pig
产品应用 WB=1:500-2000, IHC-P=1:100-500, IHC-F=1:100-500, IF=1:100-500, ELISA=1:5000-10000
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
理论分子量 53kDa
细胞定位 细胞浆 细胞膜 
性    状 Liquid
浓    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from mouse IRS-3: 261-360/494 
亚    型 IgG
纯化方法 affinity purified by Protein A
缓 冲 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
注意事项 This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed PubMed
产品介绍 The family of insulin receptor substrates (IRSs) has been reported to play important roles for signal transduction of various hormones. Four members of the IRS family have been described. Each IRS is believed to have different functions; however, the distinct physiological roles of each IRS are unclear. IRS-1 may mediate the control of various cellular processes by insulin. When phosphorylated by the insulin receptor binds specifically to various cellular proteins containing SH2 domains such as phosphatidylinositol 3-kinase p85 subunit or GRB2.

SWISS:
O54718

Gene ID:
16369

Database links:


Entrez Gene: 16369 Mouse

SwissProt: O54718 Mouse





胰岛素受体底物-3属于IRS家族。IRS作为insulin/IGF 信号途径的核心介子对细胞的生长、发育及新陈代谢的调节起关键作用。
产品图片
Sample:
Lane 1: Adipose (Rat) Lysate at 40 ug
Primary: Anti-IRS3 (bs-0186R) at 1/1000 dilution
Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
Predicted band size: 60 kD
Observed band size: 60 kD
Paraformaldehyde-fixed, paraffin embedded (rat brain tissue); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (IRS3) Polyclonal Antibody, Unconjugated (bs-0186R) at 1:400 overnight at 4°C, followed by operating according to SP Kit(Rabbit) (sp-0023) instructionsand DAB staining.
Tissue/cell: human pneumonia tissue; 4% Paraformaldehyde-fixed and paraffin-embedded;
Antigen retrieval: citrate buffer ( 0.01M, pH 6.0 ), Boiling bathing for 15min; Block endogenous peroxidase by 3% Hydrogen peroxide for 30min; Blocking buffer (normal goat serum,C-0005) at 37℃ for 20 min;
Incubation: Anti-IRS-3 Polyclonal Antibody, Unconjugated(bs-0186R) 1:200, overnight at 4°C, followed by conjugation to the secondary antibody(SP-0023) and DAB(C-0010) staining
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