| 产品编号 | bs-0064R |
| 英文名称 | Neurokinin 1 Receptor |
| 中文名称 | P物质受体抗体 |
| 别 名 | Neurokinin 1; Neurokinin 1 Receptor; NK 1 receptor; NK 1R; NK1 receptor; NK-1R; NK1R; NKIR; SPR; Substance P receptor; TAC 1R; TAC1R; Tachykinin 1 receptor; Tachykinin receptor 1; Tachykinin receptor 1; TACR1. NK1-R |
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Specific References (6) | bs-0064R has been referenced in 6 publications.
[IF=7.727] Jinbo Li. et al. Low dose shikonin and anthracyclines coloaded liposomes induce robust immunogenetic cell death for synergistic chemo-immunotherapy. J Control Release. 2021 Jul;335:306 IHC ; Mouse.
[IF=3.889] Jimei Zhang. et al. Stigmasterol alleviates allergic airway inflammation and airway hyperresponsiveness in asthma mice through inhibiting substance-P receptor. PHARM BIOL. 2023;61(1):449-458 IF ; Human.
[IF=3.877] Zhang et al. Effects of Neuropeptide Substance P on Proliferation and β-Cell Differentiation of Adult Pancreatic Ductal Cells. (2018) Front.Neurosci. 12:807 IHC ; Rat.
[IF=1.966] Tian L et al. Gingerol inhibits cisplatin-induced acute and delayed emesis in rats and minks by regulating the central and peripheral 5-HT, SP, and DA systems. J Nat Med. 2019 Nov 25. IHC-P ; rat&mink.
[IF=0] 任绪莹, et al. "小半夏汤对水貂呕吐模型作用机制的研究." Acta Neuropharmacologica 1.3 (2011). WB ; Other Species.
[IF=0] 杨玉玲, et al. "姜辣素辅助昂丹司琼对顺铂所致大鼠异嗜行为的抑制作用." 世界华人消化杂志 19.10 (2011): 1034-1039. IHC-F ; Rat.
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| 研究领域 | 神经生物学 新陈代谢 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Rat,Human (predicted: GuineaPig,Horse,Cow,Pig,Dog,Mouse) |
| 产品应用 | WB=1:500-2000, IF=1:100-500, ELISA=1:5000-10000
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 理论分子量 | 45kDa |
| 细胞定位 | 细胞膜 |
| 性 状 | Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human SPR: 2-50/407 <Extracellular> |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 缓 冲 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| PubMed | PubMed |
| 产品介绍 |
This gene belongs to a gene family of tachykinin receptors. These tachykinin receptors are characterized by interactions with G proteins and contain seven hydrophobic transmembrane regions. This gene encodes the receptor for the tachykinin substance P, also referred to as neurokinin 1. The encoded protein is also involved in the mediation of phosphatidylinositol metabolism of substance P. [provided by RefSeq, Sep 2008] Function: This is a receptor for the tachykinin neuropeptide substance P. It is probably associated with G proteins that activate a phosphatidylinositol-calcium second messenger system. The rank order of affinity of this receptor to tachykinins is: substance P > substance K > neuromedin-K. Subunit: Interacts with ARRB1 Subcellular Location: Cell membrane; Multi-pass membrane protein. Similarity: Belongs to the G-protein coupled receptor 1 family. SWISS: P25103 Gene ID: 6869 Database links: Entrez Gene: 6869 Human Entrez Gene: 21336 Mouse Omim: 162323 Human SwissProt: P25103 Human SwissProt: P30548 Mouse Unigene: 633301 Human Unigene: 8055 Mouse Unigene: 89609 Rat 此抗体与大、小鼠、及豚鼠均有交叉反应。P物质是由11个氨基酸组成的多肽，主要分布于感觉神经纤维、后根神经节和脊髓后角，作为重要的神经递质或调制因子参与伤害性刺激的传递，该递质与突触后膜上P物质受体结合，将痛冲动传入中枢，产生疼痛反应。 P物质与神经源性炎症、瘙痒及疼痛的产生有关，通过刺激肥大细胞释放组织胺、缓激肽及前列腺素等致炎、致敏、致痛物质，引起一系列病理反应，P物质除作为伤害性信息的信使外，本身又为炎症介质。 |
| 产品图片 |
Sample:
Lane 1: Human SH-SY5Y cell lysates
Lane 2: Human U87MG cell lysates
Lane 3: Human U251 cell lysates
Lane 4: Human HeLa cell lysates
Primary: Anti-Neurokinin 1 Receptor (bs-0064R) at 1/1000 dilution
Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
Predicted band size: 45 kDa
Observed band size: 50 kDa
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| 1、抗体溶解方法 | |
| 2、抗体修复方式 | |
| 3、常用试剂的配制 | |
| 4、免疫组化操作步骤 | |
| 5、免疫组化问题解答 | |
| 6、Western Blotting 操作步骤 | |
| 7、Western Blotting 问题解答 | |
| 8、关于肽链的设计 | |
| 9、多肽的溶解与保存 | |
| 10、酶标抗体效价测定程序 | |
